Sono-Photo Dynamic Therapy (SPDT)

SPDT is an approved & proven tumor destruction therapy!

Integrative Cancer Therapy Centers (ICTC) exclusively offers Sono-Photo Dynamic Therapy in Mexico, Europe, and South America Centers. 

ICTC are the only centers in Europe and the Middle East that incorporate the use of Sono-Photo Dynamic Therapy which is non-toxic, safe, effective and proven tumor destruction therapy.

The principle of SPDT was first proposed over 100 years ago. It was not until the late 1990s that it became what it is today; a safe, effective, non invasive and non-toxic way to treat cancer.

What is Sono PhotoDynamic Therapy?

SPDT is systemic photo dynamic therapy. Photodynamic means activated by photons (light). The substance that gets activated is called a sensitizer (SPS).
 We use SPDT both systemically and semi-locally. Systemically means it is used to treat the whole body, and semi-locally means it is used to treat a fairly large local area of the body. This is in contrast to surgery and radiation therapies, which are both by necessity, local therapies. The surgeon removes a single tumor or "lump", and the radiation therapist treats a small area of the body. These therapies are too damaging for extensive use.

Sono Dynamic Therapy (SDT) is sono-dynamic therapy. It is similar to SPDT except that the sensitizer is activated by sound rather than by light. SDT is a semi-local therapy.

We use both SPDT and SDT together in our treatment centers for maximum results.

Why Use Two Therapies?

Because the two together work better than either alone. Our general strategy is to intensively treat the areas where cancer is present or is likely to be present with the semi-local SPDT and SDT, and the whole body with less intense systemic SPDT. "If the cancer can be anywhere, we have to treat everywhere". 
SDT should do best with deeper tumors, because the body transmits sound better than light. Further, there is research evidence that both therapies used together are more effective than light alone.

How Does It Work?

Photo Dynamic therapy (PDT) uses non-toxic photo-sensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumor microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumor by leukocytes, and might increase the presentation of tumor-derived antigens to T cells.

PDT has been used therapeutically for about 100 years, there are 8,600 + research articles about it.

What Does SPDT / SDT Do?

These therapies kill cancer. It is as simple as that. They are an extremely effective treatment for any type of cancer and are safe, approved and effective. That is why we choose to use them in all our centers.

How do you know that SPDT/SDT kills cancer?

There is a range of evidence:

  1. Independent evidence, such as improved scans, improved or normalized tumor marker values, disappearance of detectable cancer, such as hard nodules (cancer) on the prostate. Photodynamic diagnosis, where relevant can provide particularly impressive evidence. It may show tumors before treatment, and then their progressive disappearance as treatment progresses.
  2. Subjective evidence, such as improved health, less pain, better breathing, better sleep, longer than expected freedom from evidence of cancer.

How Good is SPDT / SDT Therapy?

In SPDT/SDT there is no evidence of damage to long term users of the SPDT/SDT. Unlike, chemotherapy and radiation where too much toxicity or too much damage are the barriers.

How Much Treatment Will I need?

Assuming it can be done, best strategy is to continue treatment until there is no evidence of cancer. 
It is a good idea to follow this program, no matter what stage the cancer, and no matter what therapies are chosen.

What is the advantages of using SPDT/SDT?

Because it kills cancer without longer term damage. This makes it highly acceptable to patients, and it can be repeated as necessary.
Conventional cancer therapies may well be effective, but treatment may be limited by long term damage, and the therapy may ultimately fail.

Surgery - is often very effective, but cannot be repeated very often. Each time the patient loses healthy tissue.

Radiation therapy - is damaging, and patients have a maximum lifetime dose.

Chemotherapy - the body usually builds upe dose. resistance to chemotherapy. Different drugs can be used, usually with increasing toxicity and decreasing tolerance by both the body and the patient. Even if initially effective, chemotherapy may (after a while) cease to be effective.

With SPDT/SDT however, there is no evidence of long term damage, and no evidence that it loses effectiveness. As far as we know, it can be repeated as necessary to treat existing cancer, and to treat any recurrences.

When does SPDT/SDT fail?

  • Factors relating to the patient.
  • Waiting too long before getting SPDT/SDT therapy, often reaching the stage where complete recovery is impossible It is important to avoid wasting time with treatments which are not likely to be effective.
  • Not getting enough SPDT/SDT therapy, after it has shown evidence of benefit.
  • Being in too poor general health.
  • Having no great interest in surviving the disease.
  • Having medical problems that preclude the use of SPDT/SDT. For example, cancer invading a large blood vessel.
  • Too demoralized from the side effects of previous treatment, and from gloomy prognoses, causing the patient to give up hope.

FAQ's About SPDT

Who developed these therapies?
Photodynamic therapy (PDT) has been known for about a century. Systemic PDT (SPDT) required the development of a new class of photosensitizer, typically derivatives of chlorin e6. These have only been available for about 15 years. Our main sensitizer was developed by Dr Don Burke and colleagues in Boston , USA .

How important is diagnosis of the type of cancer?
SPDT/SDT is not very dependent on knowledge of the type of cancer. What our doctors do need to know is the size and approximate location of the primary tumor (if still present), and to have a general indication of where metastases may be. This information is usually available from scans, from photodynamic diagnosis, and from our doctor's knowledge of typical cancer migration pathways.
Conventional therapies need to know the above and a lot more. Chemotherapy and hormone therapy are dependent on accurate diagnosis of the type of cancer. Radiation therapy and surgery are both dependent on an accurate knowledge of where the tumors are.

When is it best to get these therapies?
The earlier the better. To maximize the probability of success, it is best to do SPDT/SDT shortly after diagnosis and (usually) surgery, no matter whether the surgery was "successful" or not.

What should I do before starting SPDT/SDT?
Everything you can to improve your general health and to build up a positive attitude and determination to overcome the disease.

Will there be side effects?
Except for late stage patients, the only likely side effect during treatment is tiredness. Make sure that you get enough rest.

Will there be side benefits?
Patients can experience improved energy, improved appetite, weight gain, easier breathing and less pain. Patients sometimes report benefits that are not likely to be related to reduction in the tumor load.

How safe is the sensitizer?
Our main sensitizer is a tin complex of chlorophyllin, and it has impeccable safety qualifications. Over the last 30 years, tin complexes of chlorophyllin have been used in quantities up to about 2 grams to treat new born babies with elevated bilirubin levels. It is very safe.

How does the sensitizer selectively bind to cancer cells?
Different sensitizers may have different mechanisms of action. Cancer cells have an anaerobic (no oxygen) metabolism and produce lactate. Healthy cells have an aerobic (oxygen) mechanism. The sensitizer molecule with its positive charge binds to the negatively charged lactate in the cancer cell. It is less tightly held by healthy cells.

What is the mechanism of action in killing the cancer?
It is the same for both SPDT and SDT. Light or sound activation raises the energy level of the sensitizer, producing an "activated "molecule. This is turn reacts with nearby oxygen to form "free radical"oxygen. This is a super powerful oxidant, so powerful that it is quite unstable and it reacts with the nearest oxidizable material - the organic matter in the cancer cell. This breaks down the organic matter, destroying the cells structure, and killing or damaging the cell. The free radical oxygen has a very small radius of action, so it only damages the cells that it is in - the cancer cells.

Are there new developments in progress?<
Absolutely. We the Integrative Cancer Therapy team are always looking for new developments and new technologies to improve our treatments and find the best way possible to combat cancer and give our patients a fighting chance to live.

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